BrainSignsLab - CO2 cerebrovascular reactivity measured with

Journal article

Sandeepa Sur, Zixuan Lin, Yang Li, S. Yasar, P. Rosenberg, A. Moghekar, S. Agarwal, Xirui Hou, Dengrong Jiang, R. Kalyani, Kaisha Hazel, George Pottanat, Cuimei Xu, Peter van Zijl, J. Pillai, Peiying Liu, M. Albert, Hanzhang Lu
Alzheimer's & Dementia, 2020

Semantic Scholar DOI

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APA Click to copy
Sur, S., Lin, Z., Li, Y., Yasar, S., Rosenberg, P., Moghekar, A., … Lu, H. (2020). CO2 cerebrovascular reactivity measured with phase‐contrast MRI: A potential biomarker of cognition and physical function in older adults. Alzheimer's &Amp; Dementia.

Chicago/Turabian Click to copy
Sur, Sandeepa, Zixuan Lin, Yang Li, S. Yasar, P. Rosenberg, A. Moghekar, S. Agarwal, et al. “CO2 Cerebrovascular Reactivity Measured with Phase‐Contrast MRI: A Potential Biomarker of Cognition and Physical Function in Older Adults.” Alzheimer's & Dementia (2020).

MLA Click to copy
Sur, Sandeepa, et al. “CO2 Cerebrovascular Reactivity Measured with Phase‐Contrast MRI: A Potential Biomarker of Cognition and Physical Function in Older Adults.” Alzheimer's &Amp; Dementia, 2020.

BibTeX Click to copy

@article{sandeepa2020a,
  title = {CO2 cerebrovascular reactivity measured with phase‐contrast MRI: A potential biomarker of cognition and physical function in older adults},
  year = {2020},
  journal = {Alzheimer's & Dementia},
  author = {Sur, Sandeepa and Lin, Zixuan and Li, Yang and Yasar, S. and Rosenberg, P. and Moghekar, A. and Agarwal, S. and Hou, Xirui and Jiang, Dengrong and Kalyani, R. and Hazel, Kaisha and Pottanat, George and Xu, Cuimei and van Zijl, Peter and Pillai, J. and Liu, Peiying and Albert, M. and Lu, Hanzhang}
}

Abstract

Vascular cognitive decline is a prominent cause of late‐life cognitive impairment. Compared to Alzheimer’s disease(AD), there is a paucity of biomarkers for its diagnosis, stratification, and treatment monitoring. Cerebrovascular‐Reactivity(CVR) MRI measures small‐vessel dilation to vasoactive‐stimuli(e.g. CO2), and has been shown to be associated with cognitive impairment. However, previous CVR studies were based on Blood‐Oxygenation‐Level‐Dependent (BOLD) MRI signal, which reflects a complex interplay of many physiological parameters and thus presents interpretation challenges. We measured CVR using quantitative CBF‐imaging in older participants, and tested for associations with diagnosis (Healthy Control [HC] vs. mild‐cognitive‐impairment [MCI] vs. dementia) cognitive and physical function, amyloid and tau burden, and vascular risk.