APA
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Wilcock, D., Jicha, G., Blacker, D., Albert, M., D’Orazio, L. M., Elahi, F., … Greenberg, S. (2021). MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols. Alzheimer's &Amp; Dementia.
Chicago/Turabian
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Wilcock, D., G. Jicha, D. Blacker, M. Albert, Lina M. D’Orazio, F. Elahi, M. Fornage, et al. “MarkVCID Cerebral Small Vessel Consortium: I. Enrollment, Clinical, Fluid Protocols.” Alzheimer's & Dementia (2021).
MLA
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Wilcock, D., et al. “MarkVCID Cerebral Small Vessel Consortium: I. Enrollment, Clinical, Fluid Protocols.” Alzheimer's &Amp; Dementia, 2021.
BibTeX Click to copy
@article{d2021a,
title = {MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols},
year = {2021},
journal = {Alzheimer's & Dementia},
author = {Wilcock, D. and Jicha, G. and Blacker, D. and Albert, M. and D’Orazio, Lina M. and Elahi, F. and Fornage, M. and Hinman, J. and Knoefel, J. and Kramer, J. and Kryscio, R. and Lamar, M. and Moghekar, A. and Prestopnik, Jillian and Ringman, J. and Rosenberg, G. and Sagare, A. and Satizabal, C. and Schneider, J. and Seshadri, S. and Sur, Sandeepa and Tracy, R. and Yasar, S. and Williams, Victoria J. and Singh, Herpreet and Mazina, Lidiya and Helmer, K. and Corriveau, R. and Schwab, K. and Kivisäkk, Pia and Greenberg, S.}
}
The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple contributing pathologies and (2) along with the preeminent role of Alzheimer's disease (AD) pathology, cerebrovascular disease accounts for a substantial proportion of this contribution. Contributing cerebrovascular processes include both overt strokes caused by etiologies such as large vessel occlusion, cardioembolism, and embolic infarcts of unknown source, and frequently asymptomatic brain injuries caused by diseases of the small cerebral vessels. Cerebral small vessel diseases such as arteriolosclerosis and cerebral amyloid angiopathy, when present at moderate or greater pathologic severity, are independently associated with worse cognitive performance and greater likelihood of dementia, particularly in combination with AD and other neurodegenerative pathologies. Based on this evidence, the US National Alzheimer's Project Act explicitly authorized accelerated research in vascular and mixed dementia along with frontotemporal and Lewy body dementia and AD itself.