BrainSignsLab - Acceleration of Brain Atrophy and Progression From

Journal article

Y. Uchida, K. Nishimaki, Anja Soldan, A. Moghekar, Marilyn S. Albert, Kenichi Oishi
JAMA Network Open, 2024

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Uchida, Y., Nishimaki, K., Soldan, A., Moghekar, A., Albert, M. S., & Oishi, K. (2024). Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment. JAMA Network Open.

Chicago/Turabian Click to copy
Uchida, Y., K. Nishimaki, Anja Soldan, A. Moghekar, Marilyn S. Albert, and Kenichi Oishi. “Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment.” JAMA Network Open (2024).

MLA Click to copy
Uchida, Y., et al. “Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment.” JAMA Network Open, 2024.

BibTeX Click to copy

@article{y2024a,
  title = {Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment},
  year = {2024},
  journal = {JAMA Network Open},
  author = {Uchida, Y. and Nishimaki, K. and Soldan, Anja and Moghekar, A. and Albert, Marilyn S. and Oishi, Kenichi}
}

Abstract

Key Points Question What factors are associated with the acceleration of brain atrophy and progression to mild cognitive impairment (MCI) based on long-term longitudinal data for individuals with normal cognition at baseline? Findings In the cohort study, 185 participants with normal cognition underwent a mean follow-up of 20 years with brain magnetic resonance imaging scans. Type 2 diabetes and abnormal amyloid-β concentration in the cerebrospinal fluid were associated with accelerated brain atrophy and an earlier progression to MCI. Meaning These results support the importance of identifying individuals who have accelerated brain atrophy to optimize strategies to prevent MCI.