White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status


Journal article


Kyle C Kern, Manu Vohra, M. Thirion, Danny J. J. Wang, Donna M. Wilcock, Jeffrey F Thompson, Gary A. Rosenberg, A. Sagare, A. Moghekar, Hanzhang Lu, Tiffany Lee, Fanny M. Elahi, C. Satizabal, Russell P. Tracy, Sudha Seshadri, Kristin Schwab, Karl G Helmer, Herpreet Singh, Pia Kivisäkk, Steven M. Greenberg, Keith Vossel, Joel H. Kramer, Pauline Maillard, Charles DeCarli, Jason D Hinman
Alzheimer's & Dementia, 2024

Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Kern, K. C., Vohra, M., Thirion, M., Wang, D. J. J., Wilcock, D. M., Thompson, J. F., … Hinman, J. D. (2024). White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status. Alzheimer's &Amp; Dementia.


Chicago/Turabian   Click to copy
Kern, Kyle C, Manu Vohra, M. Thirion, Danny J. J. Wang, Donna M. Wilcock, Jeffrey F Thompson, Gary A. Rosenberg, et al. “White Matter Free Water Mediates the Associations between Placental Growth Factor, White Matter Hyperintensities, and Cognitive Status.” Alzheimer's & Dementia (2024).


MLA   Click to copy
Kern, Kyle C., et al. “White Matter Free Water Mediates the Associations between Placental Growth Factor, White Matter Hyperintensities, and Cognitive Status.” Alzheimer's &Amp; Dementia, 2024.


BibTeX   Click to copy

@article{kyle2024a,
  title = {White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status},
  year = {2024},
  journal = {Alzheimer's & Dementia},
  author = {Kern, Kyle C and Vohra, Manu and Thirion, M. and Wang, Danny J. J. and Wilcock, Donna M. and Thompson, Jeffrey F and Rosenberg, Gary A. and Sagare, A. and Moghekar, A. and Lu, Hanzhang and Lee, Tiffany and Elahi, Fanny M. and Satizabal, C. and Tracy, Russell P. and Seshadri, Sudha and Schwab, Kristin and Helmer, Karl G and Singh, Herpreet and Kivisäkk, Pia and Greenberg, Steven M. and Vossel, Keith and Kramer, Joel H. and Maillard, Pauline and DeCarli, Charles and Hinman, Jason D}
}

Abstract

Placental growth factor (PlGF) may regulate cerebrovascular permeability. We hypothesized that white matter interstitial fluid accumulation, estimated via magnetic resonance imaging (MRI) free water (FW), would explain the associations between elevated PlGF, white matter hyperintensities (WMH), and cognitive impairment.